Top Venture Capital Firms & Investors for Biotech Startups in 2025

Leading Biotech Venture Capital Firms and Investors

Biotech remains dominated by sector-specialized investors, with several top-tier venture capital firms and corporate backers leading the largest deals in 2024.

Among the most active biotech VCs were Novo Holdings, Frazier Life Sciences, Arch Venture Partners, and Forbion Ventures, all of which played key roles in financing high-growth startups and emerging biopharma innovators.

In a sign of growing crossover between biotech and Silicon Valley, leading tech-focused funds are expanding into biotech investing. Andreessen Horowitz (a16z Bio Fund) and SoftBank made high-profile biotech bets in 2024, particularly in the AI-driven drug discovery space.

For example, a16z backed Genesis Therapeutics, a biotech startup using AI to accelerate drug development, reinforcing the trend of computational biology bridging the gap between biotech and tech investing.

Key Biotech Startups and Funding Trends in 2025

Several biotech startups secured blockbuster funding rounds in 2024, underscoring the renewed investor confidence in the industry. Xaira Therapeutics, a next-generation biotech company, raised a record-breaking $1 billion launch round, marking one of the largest biotech fundings of the year. This mega-deal set the tone for a wave of $100M+ early-stage biotech financings, signaling strong institutional backing for breakthrough science.

Two standout biotech startups, Seaport Therapeutics and Exsilio Therapeutics, both founded by renowned scientists with successful exits, raised Series A rounds exceeding $100–200 million each. Investors are increasingly betting on experienced biotech founders, providing them with large-scale funding from the outset to accelerate drug development and commercialization.

With biotech investment at an all-time high, a wave of AI-powered drug discovery startups, and pharmaceutical giants increasingly backing venture-stage innovation, 2025 is set to be a transformative year for biotech startups and investors.