1confirmation is a venture capital firm established in 2017, specializing in the cryptocurrency sector. Founded by Nick Tomaino, the firm focuses on supporting exceptional founders who are driving the decentralization of the web and society. With over $1 billion in assets under management, 1confirmation has invested in notable projects such as OpenSea, Coinbase, dYdX, Ethereum, and Nexus Mutual.

The firm's investment strategy emphasizes building strong partnerships with founders to effectively support their ventures. In 2021, 1confirmation raised $125 million for its third fund, significantly larger than its previous funds, aligning with its commitment to projects that advance decentralized technology and empower individuals. Early backers include Mark Cuban, Marc Andreessen, Balaji Srinivasan, and Brendan Eich.