645 Ventures is an early-stage venture capital firm founded in 2014 by Nnamdi Okike and Aaron Holiday. The firm focuses on partnering with exceptional founders building iconic technology companies, investing primarily at the Seed and Series A stages. Their investment strategy emphasizes vertical and horizontal SaaS, infrastructure software, consumer categories such as online marketplaces, and Crypto/Web3.

Since its inception, 645 Ventures has grown its assets under management to over $550 million, with a portfolio that includes notable companies like Iterable, FiscalNote, Goldbelly, Panther Labs, and Overtime. The firm employs a unique approach by leveraging proprietary software and a dedicated Success Team to provide value-added resources, assisting founders with customer acquisition, talent recruitment, marketing, public relations, and capital raising. This model has contributed to the firm's portfolio companies scaling to over $2 billion in revenues and creating nearly 4,000 new jobs in less than a decade.

In December 2022, 645 Ventures closed its oversubscribed fourth fund, Fund IV, totaling $347 million, alongside the launch of its first opportunity fund, Select I. These funds enable the firm to continue supporting early-stage founders and follow-on with larger investments in its best-performing companies at the growth stage.