Differential Ventures is an AI-native venture capital firm led by data scientists and entrepreneurs, focusing on data-centric B2B technology companies. They invest in early-stage startups, typically at the pre-seed and seed stages, with initial check sizes ranging from $250,000 to $3,000,000. Their primary investment themes include AI-Powered Business, Advancing the ML Technology Stack, The Future of Engineering and Infrastructure, and Responsible Data Management and Information Analysis.

The firm emphasizes providing hands-on support to portfolio companies, leveraging their team's extensive operational, technical, and investing experience to assist with challenges such as critical hires and complex technical hurdles.