Elm Street Ventures is a seed and early-stage venture capital firm based in New Haven, Connecticut, with Yale University as its largest investor. Since its inception in 2006, the firm has focused on supporting Yale faculty engaged in cutting-edge research addressing some of the world's most pressing challenges. Their investment thesis centers on the belief that exceptional people and groundbreaking science lead to significant impact.

Elm Street Ventures has a strong emphasis on the life sciences sector, with approximately 70% of its investments directed towards companies developing therapeutics, laboratory tools, diagnostics, medical devices, and other healthcare-related products and services. Additionally, the firm actively invests in software, materials, sustainable technology, and other industries. The firm's strategy involves identifying extraordinary investment opportunities based on Yale research, leveraging its deep connections within Yale's scientific, engineering, and clinical faculty, as well as the broader entrepreneurial ecosystem.

While the primary focus is on companies with a Yale connection, Elm Street Ventures also invests in companies located in the greater New Haven area and, in exceptional cases, non-Yale/non-New Haven companies where they have strong personal connections to the founders or investors or where they can add substantial value. In making investment decisions, Elm Street Ventures places significant emphasis on the strength of the team, valuing creative thinking, high intelligence, passion, and a deep commitment to hard work. The firm typically makes initial investments ranging from several hundred thousand dollars to over $1 million, with substantial capital reserved for follow-on investments.

They are open to syndicating with other investors who share their views and approach to investing.