Impact Science Ventures (ISV) is a venture capital firm based in San Francisco, California, founded in 2021. The firm focuses on investing in early-stage companies that are addressing critical challenges in various sectors, including energy, materials, biotechnology, manufacturing, semiconductors, and agriculture. By supporting fundamental scientific breakthroughs, ISV aims to empower leading innovators to develop solutions that can significantly impact these industries.

ISV works closely with portfolio founders to accelerate technology de-risking, verify product-market fit, and reduce time and resources to market. Their goal is to redefine industries globally while meeting critical climate goals and feeding a growing world sustainably. The firm's investment approach emphasizes cost-efficient production, supply chain resilience, and the shift to cleaner, cheaper energy and materials.

ISV's team comprises experienced professionals, including Managing Partners and Co-Founders Alain Harrus and Robert Ethier, who have backgrounds in supporting scientific entrepreneurs and innovations. The firm has made several investments in companies such as AirMyne, Brimstone, Fervo Energy, Aepnus Technology, and SirenOpt, among others. ISV is also the co-creator of a new investment partnership program at Activate, aiming to bring together early-stage technology investors and Activate cohort companies.

This initiative reflects ISV's commitment to fostering innovation and supporting the growth of impactful startups.