Intersouth Partners is a venture capital firm based in Durham, North Carolina, specializing in early-stage investments in technology and life science companies across the Southeastern United States. Established in 1985, the firm has invested in over 100 private companies and manages $780 million across seven venture capital limited partnerships, making it one of the largest venture capital funds in the Southeast. ( Intersouth focuses on sectors such as software, semiconductors, digital media, clean technology, and security in technology, and medical devices, biopharmaceuticals, and agricultural biotechnology in life sciences.

The firm typically leads or co-leads investment rounds, making initial equity investments ranging from $500,000 to $8 million, with an average total investment of $12 million per company over multiple financing rounds. ( Intersouth's experienced team offers full-cycle support, including technology assessment, management team development, corporate partnering, sales growth, and successful exits. As of now, Intersouth Partners is not making new investments.