Lowercase Capital was a prominent American venture capital firm founded in 2010 by Chris Sacca. The firm specialized in seed and early-stage investments, backing several high-profile startups that have since become household names. Notable investments included Twitter, Uber, Instagram, Twilio, and Kickstarter.

These strategic investments contributed to Lowercase Capital's reputation as one of the most successful venture capital firms of its time, with reports indicating returns of at least $5 billion to its investors. In 2017, Chris Sacca announced his retirement from venture capital to focus on climate action and political initiatives, leading to the closure of Lowercase Capital to new investments. However, the firm continued to support its existing portfolio companies.

In 2021, Sacca re-entered the venture capital scene with a renewed focus on climate-related investments through a new fund, Lowercarbon Capital.