Main Sequence Ventures is Australia's deep tech investment fund, established in 2017 by the Commonwealth Scientific and Industrial Research Organisation (CSIRO). The firm focuses on transforming scientific discoveries into industries that address global challenges, including decarbonisation, cybersecurity, quantum computing, and advanced semiconductor technology. Main Sequence Ventures employs a 'Venture Science' model, collaborating closely with scientists, researchers, and industry partners to build and scale companies that have a significant societal impact.

Over the years, the firm has invested in 53 companies, creating over 2,100 new jobs and achieving a combined market value exceeding $6.8 billion AUD. Notable portfolio companies include Regrow, Advanced Navigation, and Q-CTRL. In July 2023, Main Sequence Ventures raised $450 million AUD for its third fund, surpassing $1 billion AUD in total funds under management.