Polychain Capital is an American investment firm based in San Francisco, California, specializing in cryptocurrency and blockchain technology investments. Founded in 2016 by Olaf Carlson-Wee, the firm has attracted investments from prominent venture capital firms such as Andreessen Horowitz, Sequoia Capital, Union Square Ventures, and Founders Fund. Polychain Capital manages assets worth $5 billion as of 2024.

The firm's portfolio includes notable companies like Coinbase, Kik Messenger, and Tezos. Polychain Capital has also participated in significant funding rounds, including a $43 million Series A round for Sahara AI in August 2024, alongside Pantera Capital and Binance Labs. The firm is led by CEO Olaf Carlson-Wee, who was the first employee at Coinbase and was named in Forbes' 30 Under 30 list in 2018.