Polychain Capital is a San Francisco-based investment firm specializing in cryptocurrency and blockchain technology investments. Founded in 2016 by Olaf Carlson-Wee, the first employee at Coinbase, the firm manages portfolios of blockchain-based digital assets, aiming to generate significant returns for its investors. Notable investors include Andreessen Horowitz, Sequoia Capital, Union Square Ventures, and Founders Fund.

Polychain has invested in companies such as Coinbase, Kik Messenger, and Tezos. In July 2023, the firm raised $200 million in the first close of its fourth fund, targeting a total of $400 million. The firm has approximately $2.6 billion in assets under management.