S3 Ventures, established in 2005 and based in Austin, Texas, is the largest venture capital firm focused on Texas-based startups. The firm is uniquely backed by a single philanthropic limited partner—a multi-billion-dollar family foundation dedicated to addressing social inequities through initiatives such as community and maternal health services, early-childhood education, criminal justice reform, and inclusive neighborhood development. This singular backing allows S3 Ventures to operate without the typical fundraising pressures, enabling them to provide patient capital and true resources to entrepreneurs.

Over the past 20 years, S3 Ventures has invested in over 60 companies, with portfolio companies collectively raising more than $2 billion and achieving over 30 successful exits valued at over $3 billion. ( The firm's investment focus spans three sectors: Business Technology, Digital Experiences, and Healthcare Technology. S3 Ventures leads Seed, Series A, and Series B investments, with initial investments ranging from $500K to $10M and the capacity to invest over $20M throughout a company's lifecycle.

Notable exits include Alkami Technology's IPO in 2021, the $500 million acquisition of Levelset by Procore Technologies, and the $160 million acquisition of Acessa Health by Hologic. The firm's team comprises experienced entrepreneurs, operators, and investors committed to delivering patient capital, true resources, and big impacts to visionary founders.