Sandalphon Capital is a Midwest-based venture capital firm specializing in early-stage investments, focusing on Pre-Seed, Seed, and Series A funding rounds. The firm is named after "Sandalphon," the tallest angel, symbolizing their role as protectors and supporters of startups. Their mission is to be a helpful partner to entrepreneurs, maximizing the probability of successful outcomes for all stakeholders.

Sandalphon Capital hosts midwest.tech/connect, a virtual summit connecting Midwest-based and Midwest-linked startups with venture capitalists and angel investors. Their investment themes include Digital Transformation, enabling incumbents through technology, and Digital Reinvention, displacing incumbents through enterprise-wide tech-driven business models. The firm primarily invests in B2B SaaS and marketplace business models, focusing on sectors such as Digital Health, Healthcare IT, Insurtech, FinTech, PropTech, and GovTech.

They do not currently invest in crypto, life sciences, biotech, pharmaceuticals, medical devices, or advanced materials. Geographically, Sandalphon Capital invests across the U.S., with deep roots in Chicago, the Midwest, and other underserved markets, typically avoiding investments in the Bay Area.