Wireframe Ventures is a venture capital firm headquartered in San Francisco, California, dedicated to investing in technology that builds a better world. Founded in 2016, the firm specializes in supporting seed-stage founders who are committed to improving health and sustainability. Wireframe Ventures focuses on sectors such as climate technology, biotechnology, and health technology, aiming to partner with founders from the inception of their startups by providing not only capital but also strategic guidance and hands-on support.

The firm's investment philosophy centers on backing companies that harness biology to engineer better products, create scalable solutions to climate change, deliver personal and proactive healthcare, and deploy AI and automation to empower society. Notable investments include companies like SPAN, Mammoth Biosciences, and Electriphi. As of April 2022, Wireframe Ventures raised $77 million for its second early-stage venture health and climate fund, focusing on pre-seed and seed investments.